Iridium-Catalyzed Reductive Coupling of Grignard Reagents and Tertiary Amides
نویسندگان
چکیده
منابع مشابه
Tertiary amine synthesis via reductive coupling of amides with Grignard reagents† †Electronic supplementary information (ESI) available: Experimental procedures, spectroscopic data, copies of 1H and 13C NMR spectra and crystallographic data. CCDC 1552384. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc03613b Click here for additional data file. Click here for additional data file.
A new iridium catalyzed reductive coupling reaction of Grignard reagents and tertiary amides affording functionalised tertiary amine products via an efficient and technically-simple one-pot, two-stage experimental protocol, is reported. The reaction – which can be carried out on gram-scale using as little as 1 mol% Vaska's complex [IrCl(CO)(PPh3)2] and TMDS as the terminal reductant for the ini...
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ژورنال
عنوان ژورنال: Organic Syntheses
سال: 2019
ISSN: 2333-3553
DOI: 10.15227/orgsyn.096.0511